BAIT

MARCKS

80K-L, MACS, PKCSL, PRKCSL
myristoylated alanine-rich protein kinase C substrate
Alzheimer's Disease Project
GO Process (3)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

MRPL49

C11orf4, L49mt, MRP-L49, NOF, NOF1, OK/SW-cl.67
mitochondrial ribosomal protein L49
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.

Eustace NJ, Anderson JC, Langford CP, Trummell HQ, Hicks PH, Jarboe JS, Mobley JA, Hjelmeland AB, Hackney JR, Pedersen RT, Cosby K, Gillespie GY, Bonner JA, Willey CD

Glioblastoma harbors frequent alterations in receptor tyrosine kinases, phosphatidylinositol?3 kinase (PI3K) and phosphatase and tensin homolog (PTEN) that dysregulate phospholipid signaling driven tumor proliferation and therapeutic resistance. Myristoylated alanine?rich C?kinase substrate (MARCKS) is a 32 kDa intrinsically unstructured protein containing a polybasic (+13) effector domain (ED), which regulates its electrostatic sequestration of phospholipid phosphatidylinositol (4,5)?bisphosphate (PIP2), and its binding to phosphatidylserine, calcium/calmodulin, filamentous actin, while ... [more]

Int. J. Oncol. Jun. 01, 2019; 54(6);2039-2053 [Pubmed: 30942445]

Throughput

  • Low Throughput

Curated By

  • BioGRID