BAIT
BIRC3
AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2
baculoviral IAP repeat containing 3
GO Process (23)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- NIK/NF-kappaB signaling [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of necroptotic process [IBA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- positive regulation of protein ubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of RIG-I signaling pathway [TAS]
- regulation of apoptotic process [IMP]
- regulation of cysteine-type endopeptidase activity [TAS]
- regulation of inflammatory response [TAS]
- regulation of innate immune response [TAS]
- regulation of necroptotic process [IMP]
- regulation of nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- regulation of toll-like receptor signaling pathway [TAS]
- spindle assembly involved in mitosis [IBA]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP2A2
ATP2B, DAR, DD, SERCA2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GO Process (17)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion import into sarcoplasmic reticulum [IC, ISS]
- calcium ion transmembrane transport [IDA]
- calcium ion transport from cytosol to endoplasmic reticulum [IDA]
- cell adhesion [TAS]
- cellular calcium ion homeostasis [IDA]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- epidermis development [TAS]
- ion transmembrane transport [TAS]
- positive regulation of endoplasmic reticulum calcium ion concentration [IDA]
- positive regulation of heart rate [TAS]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISS]
- regulation of cardiac muscle cell membrane potential [IC, ISS, TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IDA]
- relaxation of cardiac muscle [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [IDA]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA, TAS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA]
- longitudinal sarcoplasmic reticulum [IDA]
- membrane [IDA]
- platelet dense tubular network membrane [TAS]
- sarcoplasmic reticulum [IDA]
- sarcoplasmic reticulum membrane [IC, TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.
Alternative 3' untranslated regions (3' UTRs) are widespread, but their functional roles are largely unknown. We investigated the function of the long BIRC3 3' UTR, which is upregulated in leukemia. The 3' UTR does not regulate BIRC3 protein localization or abundance but is required for CXCR4-mediated B cell migration. We established an experimental pipeline to study the mechanism of regulation and ... [more]
Mol. Cell Dec. 16, 2018; 74(4);701-712.e9 [Pubmed: 30948266]
Throughput
- High Throughput
Additional Notes
- assayed using SILAC IP (stable isotope labeling by amino acids in cell culture-based quantitative immunoprecipitation)
Curated By
- BioGRID