CXCR4
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [TAS]
- apoptotic process [TAS]
- calcium-mediated signaling [IMP]
- cellular response to cytokine stimulus [IDA]
- chemokine-mediated signaling pathway [NAS]
- dendritic cell chemotaxis [TAS]
- entry into host cell [TAS]
- inflammatory response [TAS]
- myelin maintenance [ISS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- positive regulation of oligodendrocyte differentiation [ISS]
- regulation of chemotaxis [IMP]
- response to hypoxia [IEP]
- response to virus [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RALA
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- actin cytoskeleton reorganization [IDA]
- chemotaxis [TAS]
- cytokinesis [IDA]
- membrane organization [TAS]
- membrane raft localization [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of filopodium assembly [IDA]
- regulation of exocytosis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.
Alternative 3' untranslated regions (3' UTRs) are widespread, but their functional roles are largely unknown. We investigated the function of the long BIRC3 3' UTR, which is upregulated in leukemia. The 3' UTR does not regulate BIRC3 protein localization or abundance but is required for CXCR4-mediated B cell migration. We established an experimental pipeline to study the mechanism of regulation and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID