BAIT
LMBR1L
LIMR, UNQ458/PRO783
limb development membrane protein 1-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ATP6V1H
MSTP042, NBP1, SFD, SFDalpha, SFDbeta, VMA13, CGI-11
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
GO Process (13)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [NAS]
- ATP hydrolysis coupled proton transport [NAS]
- cellular iron ion homeostasis [TAS]
- endocytosis [IDA]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- regulation of catalytic activity [NAS]
- regulation of defense response to virus by virus [TAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
- vacuolar acidification [NAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.
Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing ... [more]
Science Dec. 10, 2018; 364(6440); [Pubmed: 31073040]
Throughput
- High Throughput
Additional Notes
- hits are proteins detected in an immunoprecipitation (IP) with the bait protein but not in an IP of the vector only
- hits are proteins detected only in immunoprecipitation (IP) of the bait protein but not in a vector control IP
Curated By
- BioGRID