BAIT
LMBR1L
LIMR, UNQ458/PRO783
limb development membrane protein 1-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ADAM10
AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz
ADAM metallopeptidase domain 10
GO Process (20)
GO Function (8)
GO Component (13)
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [ISS, TAS]
- PMA-inducible membrane protein ectodomain proteolysis [IMP]
- cell-cell signaling [NAS]
- collagen catabolic process [TAS]
- constitutive protein ectodomain proteolysis [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- in utero embryonic development [ISS]
- integrin-mediated signaling pathway [NAS]
- membrane protein ectodomain proteolysis [IDA, IMP]
- monocyte activation [IMP]
- negative regulation of cell adhesion [IDA, NAS]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- protein phosphorylation [ISS]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Golgi-associated vesicle [IDA]
- cell surface [IDA]
- cytoplasm [ISS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [NAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- nucleus [ISS]
- perinuclear endoplasmic reticulum [IDA]
- plasma membrane [TAS]
- tetraspanin-enriched microdomain [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.
Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing ... [more]
Science Dec. 10, 2018; 364(6440); [Pubmed: 31073040]
Throughput
- High Throughput
Additional Notes
- hits are proteins detected in an immunoprecipitation (IP) with the bait protein but not in an IP of the vector only
- hits are proteins detected only in immunoprecipitation (IP) of the bait protein but not in a vector control IP
Curated By
- BioGRID