Publication

LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.

Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B

Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing ... [more]

Throughput

• High Throughput

Additional Notes

• hits are proteins detected in an immunoprecipitation (IP) with the bait protein but not in an IP of the vector only
• hits are proteins detected only in immunoprecipitation (IP) of the bait protein but not in a vector control IP

Curated By

• BioGRID