BAIT
LMBR1L
LIMR, UNQ458/PRO783
limb development membrane protein 1-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
SCFD1
C14orf163, RA410, SLY1, SLY1P, STXBP1L2, FKSG23
sec1 family domain containing 1
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cell morphogenesis [ISS]
- negative regulation of autophagic vacuole assembly [IMP]
- phagocytosis [ISS]
- post-Golgi vesicle-mediated transport [ISS]
- regulation of ER to Golgi vesicle-mediated transport [ISS]
- regulation of protein transport [IMP]
- response to toxic substance [IEP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.
Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing ... [more]
Science Dec. 10, 2018; 364(6440); [Pubmed: 31073040]
Throughput
- High Throughput
Additional Notes
- hits are proteins detected only in immunoprecipitation (IP) of the bait protein but not in a vector control IP
Curated By
- BioGRID