BAIT
LMBR1L
LIMR, UNQ458/PRO783
limb development membrane protein 1-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ABCD1
ABC42, ALD, ALDP, AMN
ATP-binding cassette, sub-family D (ALD), member 1
GO Process (14)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- alpha-linolenic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- fatty acid beta-oxidation [IDA, IGI]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- linoleic acid metabolic process [TAS]
- long-chain fatty acid catabolic process [IGI]
- peroxisomal long-chain fatty acid import [IGI]
- peroxisomal membrane transport [NAS]
- peroxisome organization [IDA, NAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- unsaturated fatty acid metabolic process [TAS]
- very long-chain fatty acid catabolic process [IDA, IGI]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled to transmembrane movement of substances [NAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- peroxisomal fatty-acyl-CoA transporter activity [IGI, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [NAS]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled to transmembrane movement of substances [NAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- peroxisomal fatty-acyl-CoA transporter activity [IGI, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [NAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LMBR1L regulates lymphopoiesis through Wnt/?-catenin signaling.
Precise control of Wnt signaling is necessary for immune system development. In this study, we detected severely impaired development of all lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described function in immunity. The interaction of LMBR1L with glycoprotein 78 (GP78) and ubiquitin-associated domain-containing ... [more]
Science Dec. 10, 2018; 364(6440); [Pubmed: 31073040]
Throughput
- High Throughput
Additional Notes
- hits are proteins detected only in immunoprecipitation (IP) of the bait protein but not in a vector control IP
Curated By
- BioGRID