BAIT
PGRMC1
HPR6.6, MPR
progesterone receptor membrane component 1
GO Process (0)
GO Function (2)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PNKP
EIEE10, MCSZ, PNK
polynucleotide kinase 3'-phosphatase
GO Process (10)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA, NAS]
- DNA repair [IGI]
- DNA-dependent DNA replication [NAS]
- dephosphorylation [IDA]
- nucleic acid phosphodiester bond hydrolysis [NAS]
- nucleotide phosphorylation [IDA]
- nucleotide-excision repair, DNA damage removal [NAS]
- polynucleotide 3' dephosphorylation [IDA]
- response to oxidative stress [IDA]
- response to radiation [NAS, TAS]
Gene Ontology Molecular Function- ATP binding [NAS]
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [IDA]
- damaged DNA binding [NAS]
- double-stranded DNA binding [TAS]
- endonuclease activity [NAS]
- nucleotide kinase activity [IDA]
- polynucleotide 3'-phosphatase activity [IDA]
- protein binding [IPI]
- purine nucleotide binding [NAS]
- ATP binding [NAS]
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [IDA]
- damaged DNA binding [NAS]
- double-stranded DNA binding [TAS]
- endonuclease activity [NAS]
- nucleotide kinase activity [IDA]
- polynucleotide 3'-phosphatase activity [IDA]
- protein binding [IPI]
- purine nucleotide binding [NAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.
Progesterone (P4) is a major steroid hormone that has important effects on metabolism. The progesterone receptor membrane component 1 (PGRMC1) is a non-canonical P4 binding protein. The biological functions affected by PGRMC1 include cholesterol/steroid biosynthesis and metabolism, iron homeostasis and heme trafficking, autophagy, regulation of cell cycle and proliferation, cell migration and invasion. PGRMC1 has been an attractive target for ... [more]
J. Steroid Biochem. Mol. Biol. Dec. 01, 2018; 191();105376 [Pubmed: 31067491]
Throughput
- High Throughput
Curated By
- BioGRID