BAIT
PGRMC1
HPR6.6, MPR
progesterone receptor membrane component 1
GO Process (0)
GO Function (2)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HDAC4
AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
histone deacetylase 4
GO Process (24)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- cardiac muscle hypertrophy in response to stress [TAS]
- chromatin remodeling [IDA]
- histone H3 deacetylation [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA, IMP]
- inflammatory response [TAS]
- negative regulation of glycolytic process [ISS]
- negative regulation of myotube differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nervous system development [TAS]
- peptidyl-lysine deacetylation [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of protein sumoylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of gene expression, epigenetic [IMP]
- regulation of protein binding [IMP]
- response to denervation involved in regulation of muscle adaptation [ISS]
- response to interleukin-1 [IMP]
Gene Ontology Molecular Function- activating transcription factor binding [IPI]
- core promoter binding [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein deacetylase activity [IDA]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
- activating transcription factor binding [IPI]
- core promoter binding [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein deacetylase activity [IDA]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.
Progesterone (P4) is a major steroid hormone that has important effects on metabolism. The progesterone receptor membrane component 1 (PGRMC1) is a non-canonical P4 binding protein. The biological functions affected by PGRMC1 include cholesterol/steroid biosynthesis and metabolism, iron homeostasis and heme trafficking, autophagy, regulation of cell cycle and proliferation, cell migration and invasion. PGRMC1 has been an attractive target for ... [more]
J. Steroid Biochem. Mol. Biol. Dec. 01, 2018; 191();105376 [Pubmed: 31067491]
Throughput
- High Throughput
Curated By
- BioGRID