BAIT

DNMT1

ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
DNA (cytosine-5-)-methyltransferase 1
Homo sapiens
PREY

EZH2-A

enx-1, enx1, ezh1, ezh2, kmt6, xez
enhancer of zeste 2 polycomb repressive complex 2 subunit
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells.

Lei A, Chen L, Zhang M, Yang X, Xu L, Cao N, Zhang Z, Cao Y

Misexpression of chromatin modification factors and changed epigenetic modifications play crucial roles for tumorigenesis. Our previous studies demonstrated that inhibition of epigenetic modification enzymes EZH2, LSD1, DNMTs, and HDACs caused post-mitotic neuron-like differentiation in different cancer cells. However, how they regulate neuronal differentiation in cancer cells was unknown. Here, we show that EZH2, LSD1, DNMT1, and HDAC1 form interactions themselves, ... [more]

Front Genet May. 28, 2019; 10();422 [Pubmed: 31130994]

Throughput

  • Low Throughput

Curated By

  • BioGRID