EFNB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RELN
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [IMP]
- associative learning [IDA]
- axon guidance [IMP]
- brain development [IMP, ISO]
- cell migration [IMP]
- cell morphogenesis involved in differentiation [IMP]
- central nervous system development [IMP]
- cerebral cortex development [IMP]
- cerebral cortex tangential migration [IMP]
- dendrite development [IGI, IMP]
- dentate gyrus development [ISO]
- forebrain development [IMP]
- glial cell differentiation [IMP]
- hippocampus development [IDA]
- lateral motor column neuron migration [IMP]
- layer formation in cerebral cortex [IMP]
- locomotory behavior [IMP, ISO]
- long-term memory [IDA]
- neuron migration [IGI, IMP, ISO]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of TOR signaling [IDA]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA]
- positive regulation of dendritic spine morphogenesis [IDA, IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA, IMP]
- positive regulation of lateral motor column neuron migration [IMP]
- positive regulation of long-term synaptic potentiation [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of small GTPase mediated signal transduction [IDA]
- positive regulation of synapse maturation [IDA]
- positive regulation of synaptic transmission, glutamatergic [IDA, IMP]
- postsynaptic density assembly [IC]
- postsynaptic density protein 95 clustering [IMP]
- protein localization to synapse [IMP]
- receptor localization to synapse [IMP]
- reelin-mediated signaling pathway [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of behavior [IMP]
- regulation of gene expression [IMP]
- regulation of synaptic transmission [IMP]
- response to pain [IMP]
- spinal cord patterning [IMP]
- thyroid hormone metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Coordinated migration of neurons in the developing and adult brain is essential for its proper function. The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by binding to two lipoprotein receptors, the very-low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2, also known as LRP8). Loss of Reelin function in humans results in the severe developmental ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID