EFNB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RELN
Gene Ontology Biological Process
- axon guidance [ISS]
- brain development [ISS]
- cell morphogenesis involved in differentiation [ISS]
- central nervous system development [ISS]
- cerebral cortex tangential migration [ISS]
- glial cell differentiation [ISS]
- hippocampus development [ISS]
- neuron migration [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of CREB transcription factor activity [ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of long-term synaptic potentiation [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of protein tyrosine kinase activity [ISS]
- positive regulation of small GTPase mediated signal transduction [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- reelin-mediated signaling pathway [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of behavior [ISS]
- regulation of synaptic transmission [ISS]
- response to pain [ISS]
- spinal cord patterning [ISS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Coordinated migration of neurons in the developing and adult brain is essential for its proper function. The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by binding to two lipoprotein receptors, the very-low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2, also known as LRP8). Loss of Reelin function in humans results in the severe developmental ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID