SLX8
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAD50
Gene Ontology Biological Process
- base-excision repair [IMP]
- double-strand break repair via break-induced replication [TAS]
- double-strand break repair via nonhomologous end joining [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA double-strand break processing [TAS]
- meiotic nuclear division [IMP]
- mitochondrial double-strand break repair via homologous recombination [IMP]
- negative regulation of endodeoxyribonuclease activity [IDA]
- telomere maintenance [IMP]
- telomere maintenance via recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination.
Recombination is important for repairing DNA lesions, yet it can also lead to genomic rearrangements. This process must be regulated, and recently, sumoylation-mediated mechanisms were found to inhibit Rad51-dependent recombination. Here, we report that the absence of the Slx5-Slx8 complex, a newly identified player in the SUMO (small ubiquitin-like modifier) pathway, led to increased Rad51-dependent and Rad51-independent recombination. The increases ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: colony appearance (APO:0000060)
- phenotype: colony shape (APO:0000062)
- phenotype: colony size (APO:0000063)
Additional Notes
- deletion rescues the nibbled colony growth defect seen in an slx8/slx5 double mutant
- genetic complex
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SLX8 RAD50 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 454651 | |
RAD50 SLX8 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 456786 |
Curated By
- BioGRID