BAIT
GABARAPL1
APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, GEC1
GABA(A) receptor-associated protein like 1
GO Process (4)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90AA1
Hsp86, Hsp90, Hspca
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (16)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IEP]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [IMP]
- positive regulation of cardiac muscle contraction [IEP]
- positive regulation of cell size [IMP]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of protein import into nucleus, translocation [IMP]
- protein folding [TAS]
- protein import into mitochondrial outer membrane [ISO]
- regulation of catalytic activity [ISO, ISS]
- response to estrogen [IEP]
- response to heat [IEP]
- response to salt stress [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border membrane [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular matrix [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein.
GABARAPL1 belongs to the small family of GABARAP proteins (including GABARAP, GABARAPL1 and GABARAPL2/GATE-16), one of the two subfamilies of the yeast Atg8 orthologue. GABARAPL1 is involved in the intracellular transport of receptors, via an interaction with tubulin and GABA(A) or kappa opioid receptors, and also participates in autophagy and cell proliferation. In the present study, we identify the HSP90 ... [more]
Biochimie Mar. 01, 2012; 94(3);748-58 [Pubmed: 22120110]
Throughput
- Low Throughput
Additional Notes
- Species of bait is unclear
Curated By
- BioGRID