BAIT
HTR3A
5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
GO Process (6)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAP1B
A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5
microtubule-associated protein 1B
GO Process (13)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
- axon extension [IMP]
- axonogenesis [IGI]
- cellular process [ISO]
- dendrite development [IMP]
- establishment of monopolar cell polarity [IMP]
- microtubule bundle formation [IMP, ISO]
- microtubule-based process [TAS]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- negative regulation of microtubule depolymerization [ISO]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of neuron differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- cytoplasm [ISO]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [ISO]
- growth cone [ISO]
- intracellular [IMP]
- microtubule associated complex [ISO, TAS]
- neuronal cell body [ISO]
- neuronal postsynaptic density [IDA]
- perikaryon [ISO]
- perinuclear region of cytoplasm [ISO]
- photoreceptor outer segment [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA, ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.
Regulation of ligand-gated ion channel (LGIC) function and trafficking by cytoskeleton proteins has been the topic of recent research. Here, we report that the light chain (LC1) of microtubule-associated protein 1B (MAP1B) specifically interacted with the 5-HT(3A) receptor, a predominant serotonin-gated ion channel in the brain. LC1 and 5-HT(3A) receptors were colocalized in central neurons and in HEK 293 cells ... [more]
J. Physiol. (Lond.) Feb. 01, 2008; 586(3);751-62 [Pubmed: 18063656]
Throughput
- Low Throughput
Additional Notes
- species of bait is unclear
Curated By
- BioGRID