KCNMA1
Gene Ontology Biological Process
- adult walking behavior [ISO]
- auditory receptor cell differentiation [ISO]
- cell maturation [ISO]
- cellular potassium ion homeostasis [ISO]
- circadian rhythm [ISO]
- eye blink reflex [ISO]
- locomotor rhythm [ISO]
- micturition [ISO]
- negative regulation of cell volume [ISO]
- neuromuscular process controlling balance [ISO]
- neuronal action potential [ISO]
- positive regulation of apoptotic process [ISO]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [ISO]
- protein homooligomerization [ISO]
- protein homotetramerization [IDA]
- regulation of aldosterone metabolic process [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of vasodilation [IDA]
- relaxation of vascular smooth muscle [ISO]
- response to calcium ion [IDA, ISO]
- response to carbon monoxide [ISO]
- response to corticosteroid [IDA]
- response to estrogen [IDA]
- response to hypoxia [IDA, ISO]
- response to osmotic stress [ISO]
- response to pH [IDA]
- saliva secretion [ISO]
- sensory perception of sound [ISO]
- smooth muscle contraction involved in micturition [ISO]
- synaptic transmission [ISO]
- vasodilation [ISO]
Gene Ontology Molecular Function- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, ISO]
- large conductance calcium-activated potassium channel activity [IBA, IDA, ISO]
- potassium channel activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein homodimerization activity [IDA]
- voltage-gated potassium channel activity [IBA, ISO]
- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, ISO]
- large conductance calcium-activated potassium channel activity [IBA, IDA, ISO]
- potassium channel activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein homodimerization activity [IDA]
- voltage-gated potassium channel activity [IBA, ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IBA, ISO]
- caveola [ISO]
- cell [ISO]
- cytoplasm [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- presynaptic active zone membrane [IDA]
- protein complex [IDA]
- terminal bouton [ISO]
- voltage-gated potassium channel complex [IBA, ISO]
MAP1A
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Direct interaction between BKCa potassium channel and microtubule-associated protein 1A.
The BKCa channel, a potassium channel that is allosterically activated by voltage and calcium, is expressed in both excitable and non-excitable cells. The channel plays an important role in regulating membrane excitability. The channel activity can be modulated by post-translational modifications such as phosphorylation. Recently, hippocampal BKCa channels were shown to be directly modulated by assembly/disassembly of the submembranous actin ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNMA1 MAP1A | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| MAP1A KCNMA1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID