BAIT

TARDBP

ALS10, TDP-43, RP4-635E18.2
TAR DNA binding protein
Homo sapiens
PREY

UBP3

BLM3, mRNA-binding ubiquitin-specific protease UBP3, L000002417, S000086717, YER151C
Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress; role in ribophagy
UPS Project
GO Process (4)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover.

Liu G, Byrd A, Warner AN, Pei F, Basha E, Buchanan A, Buchan JR

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. TDP-43 (TAR DNA-binding protein 43) and FUS (fused in sarcoma) are aggregation-prone RNA-binding proteins that in ALS can mislocalize to the cytoplasm of affected motor neuron cells, often forming cytoplasmic aggregates in the process. Such mislocalization and aggregation are implicated in ALS pathology, though the mechanism(s) of TDP-43 and ... [more]

Mol. Cell. Biol. Jan. 30, 2020; 40(4); [Pubmed: 31767634]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Figure 2
  • TDP-43 toxicity
  • in yeast

Curated By

  • BioGRID