BAIT
WWP2
AIP2, WWp2-like
WW domain containing E3 ubiquitin protein ligase 2
GO Process (16)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of gene expression [IMP]
- negative regulation of protein transport [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- negative regulation of transcription, DNA-templated [ISS]
- negative regulation of transporter activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K63-linked ubiquitination [ISS]
- protein autoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane potential [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
RPS4X
CCG2, DXS306, RPS4, S4, SCAR, SCR10
ribosomal protein S4, X-linked
GO Process (16)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- multicellular organismal development [IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of translation [IMP]
- translation [IC, IMP, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a pivotal role in transcription inhibition at DSBs by stimulating proteasome-dependent eviction of RNAPII at these lesions. How DNA-PK triggers RNAPII eviction to inhibit transcription at DSBs remains unclear. Here we show that the HECT E3 ubiquitin ... [more]
Genes Dev. Dec. 01, 2018; 33(11-12);684-704 [Pubmed: 31048545]
Throughput
- High Throughput
Additional Notes
- assayed using SILAC IP (stable isotope labeling by amino acids in cell culture-based quantitative immunoprecipitation)
Curated By
- BioGRID