DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS, TAS]
- axon guidance [TAS]
- dendritic spine morphogenesis [ISS]
- establishment of protein localization [IDA]
- learning [TAS]
- negative regulation of receptor internalization [ISS]
- nervous system development [TAS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synaptic transmission [ISS]
- protein complex assembly [IDA]
- protein localization to synapse [IDA]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
- synaptic vesicle maturation [ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISS]
- P2Y1 nucleotide receptor binding [ISS]
- PDZ domain binding [ISS]
- acetylcholine receptor binding [ISS]
- beta-1 adrenergic receptor binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISS]
- protein phosphatase binding [ISS]
- scaffold protein binding [ISS]
- D1 dopamine receptor binding [ISS]
- P2Y1 nucleotide receptor binding [ISS]
- PDZ domain binding [ISS]
- acetylcholine receptor binding [ISS]
- beta-1 adrenergic receptor binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISS]
- protein phosphatase binding [ISS]
- scaffold protein binding [ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISS]
- cell junction [ISS]
- cortical cytoskeleton [IDA]
- cytoplasm [ISS]
- dendrite cytoplasm [ISS]
- dendritic spine [ISS]
- endocytic vesicle membrane [TAS]
- endoplasmic reticulum [ISS]
- excitatory synapse [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [ISS]
- ionotropic glutamate receptor complex [ISS]
- juxtaparanode region of axon [ISS]
- neuron projection terminus [ISS]
- neuron spine [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS, TAS]
- postsynaptic density [ISS]
- postsynaptic membrane [IDA]
- synapse [IDA]
- synaptic vesicle [ISS]
- voltage-gated potassium channel complex [ISS]
LGI1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
Abnormally synchronized synaptic transmission in the brain causes epilepsy. Most inherited forms of epilepsy result from mutations in ion channels. However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1. We show that ADAM22, a transmembrane protein that when mutated itself causes seizure, serves as a receptor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLG4 LGI1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID