BAIT
FAM105A
NET20
family with sequence similarity 105, member A
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ATP6AP2
APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028
ATPase, H+ transporting, lysosomal accessory protein 2
GO Process (9)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- angiotensin maturation [IDA, TAS]
- cellular protein metabolic process [TAS]
- eye pigmentation [IMP]
- head morphogenesis [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of transforming growth factor beta1 production [IDA]
- proteolysis [EXP]
- regulation of MAPK cascade [IDA]
- rostrocaudal neural tube patterning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.
Pseudoenzymes have been identified across a diverse range of enzyme classes and fulfill important cellular functions. Examples of pseudoenzymes exist within ubiquitin conjugating and deubiquitinase (DUB) protein families. Here we characterize FAM105A/OTULINL, the only putative pseudodeubiquitinase of the ovarian tumor protease (OTU domain) family in humans. The crystal structure of FAM105A revealed that the OTU domain possesses structural deficiencies in both ... [more]
Structure Dec. 04, 2018; 27(6);1000-1012.e6 [Pubmed: 31056421]
Throughput
- High Throughput
Additional Notes
- assayed using BioID (proximity-dependent biotin identification)
Curated By
- BioGRID