BAIT
FAM105A
NET20
family with sequence similarity 105, member A
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
VTI1B
VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1
vesicle transport through interaction with t-SNAREs 1B
GO Process (12)
GO Function (3)
GO Component (13)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IBA]
- Golgi to vacuole transport [IBA]
- autophagic vacuole fusion [IMP]
- cell proliferation [TAS]
- intra-Golgi vesicle-mediated transport [IBA]
- membrane fusion [TAS]
- protein targeting to vacuole [IBA]
- regulation of protein localization to plasma membrane [IDA]
- retrograde transport, endosome to Golgi [IBA]
- vesicle docking involved in exocytosis [TAS]
- vesicle fusion with Golgi apparatus [IBA]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [IBA]
- Golgi apparatus [IDA]
- SNARE complex [IBA]
- cytoplasm [IDA]
- endoplasmic reticulum membrane [IBA]
- intracellular membrane-bounded organelle [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- neuronal cell body [ISS]
- perinuclear region of cytoplasm [IDA]
- recycling endosome [IDA]
- synaptic vesicle [ISS]
- vesicle [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.
Pseudoenzymes have been identified across a diverse range of enzyme classes and fulfill important cellular functions. Examples of pseudoenzymes exist within ubiquitin conjugating and deubiquitinase (DUB) protein families. Here we characterize FAM105A/OTULINL, the only putative pseudodeubiquitinase of the ovarian tumor protease (OTU domain) family in humans. The crystal structure of FAM105A revealed that the OTU domain possesses structural deficiencies in both ... [more]
Structure Dec. 04, 2018; 27(6);1000-1012.e6 [Pubmed: 31056421]
Throughput
- High Throughput
Additional Notes
- assayed using BioID (proximity-dependent biotin identification)
Curated By
- BioGRID