BAIT
FAM105A
NET20
family with sequence similarity 105, member A
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
WFS1
CTRCT41, WFRS, WFS, WFSL
Wolfram syndrome 1 (wolframin)
GO Process (27)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- ER overload response [IC, TAS]
- ER-associated ubiquitin-dependent protein catabolic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- calcium ion homeostasis [IDA]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- endoplasmic reticulum unfolded protein response [ISS, TAS]
- glucose homeostasis [IMP]
- kidney development [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- negative regulation of type B pancreatic cell apoptotic process [IMP]
- neurological system process [IMP]
- polyubiquitinated misfolded protein transport [ISS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of growth [ISS]
- positive regulation of protein metabolic process [IDA]
- positive regulation of protein ubiquitination [ISS]
- positive regulation of proteolysis [ISS]
- protein maturation by protein folding [IC]
- protein stabilization [ISS]
- renal water homeostasis [IMP]
- response to endoplasmic reticulum stress [IDA]
- sensory perception of sound [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.
Pseudoenzymes have been identified across a diverse range of enzyme classes and fulfill important cellular functions. Examples of pseudoenzymes exist within ubiquitin conjugating and deubiquitinase (DUB) protein families. Here we characterize FAM105A/OTULINL, the only putative pseudodeubiquitinase of the ovarian tumor protease (OTU domain) family in humans. The crystal structure of FAM105A revealed that the OTU domain possesses structural deficiencies in both ... [more]
Structure Dec. 04, 2018; 27(6);1000-1012.e6 [Pubmed: 31056421]
Throughput
- High Throughput
Additional Notes
- assayed using BioID (proximity-dependent biotin identification)
Curated By
- BioGRID