BAIT
RGS14
RPIP1
regulator of G-protein signaling 14
GO Process (21)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- cell division [ISO]
- chromosome segregation [IMP]
- intracellular signal transduction [IDA]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IDA]
- mitotic nuclear division [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of synaptic plasticity [IMP]
- nucleocytoplasmic transport [IDA, ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of neurogenesis [ISO]
- regulation of DNA-templated transcription in response to stress [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- response to oxidative stress [ISO]
- spindle organization [IMP, ISO]
- visual learning [ISO]
- zygote asymmetric cell division [IMP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
Gene Ontology Cellular Component
- centrosome [IDA, ISO]
- cytoplasm [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- dendritic spine [IDA]
- nuclear body [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IBA, IDA, ISO]
- postsynaptic density [IDA]
- spindle [IDA, ISO]
- spindle pole [ISO]
Mus musculus
PREY
SYNGAP1
Gm1963, Syngap
synaptic Ras GTPase activating protein 1 homolog (rat)
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits synaptic plasticity and hippocampus-dependent learning and memory. However, the signaling proteins that RGS14 natively engages to regulate plasticity are unknown. Here, we show ... [more]
J. Proteome Res. Dec. 06, 2017; 17(4);1700-1711 [Pubmed: 29518331]
Throughput
- High Throughput
Curated By
- BioGRID