BAIT
RGS14
RPIP1
regulator of G-protein signaling 14
GO Process (21)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- cell division [ISO]
- chromosome segregation [IMP]
- intracellular signal transduction [IDA]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IDA]
- mitotic nuclear division [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of synaptic plasticity [IMP]
- nucleocytoplasmic transport [IDA, ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of neurogenesis [ISO]
- regulation of DNA-templated transcription in response to stress [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- response to oxidative stress [ISO]
- spindle organization [IMP, ISO]
- visual learning [ISO]
- zygote asymmetric cell division [IMP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
Gene Ontology Cellular Component
- centrosome [IDA, ISO]
- cytoplasm [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- dendritic spine [IDA]
- nuclear body [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IBA, IDA, ISO]
- postsynaptic density [IDA]
- spindle [IDA, ISO]
- spindle pole [ISO]
Mus musculus
PREY
GJA1
AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, connexin43
gap junction protein, alpha 1
GO Process (58)
GO Function (10)
GO Component (24)
Gene Ontology Biological Process
- ATP transport [ISO]
- adult heart development [IMP]
- apoptotic process [ISO]
- atrial ventricular junction remodeling [IGI]
- blood vessel morphogenesis [IMP]
- cardiac conduction [IMP]
- cell communication [ISO]
- cell communication by chemical coupling [IDA]
- cell communication by electrical coupling [IDA, ISO]
- cell-cell junction organization [IMP]
- cell-cell signaling [IDA, ISO]
- chronic inflammatory response [ISO]
- embryonic digit morphogenesis [IMP]
- embryonic heart tube development [IMP]
- epicardial cell to mesenchymal cell transition [TAS]
- epithelial cell maturation [IMP]
- establishment of epithelial cell polarity [TAS]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- lens development in camera-type eye [IMP]
- milk ejection [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of wound healing [ISO]
- neuron migration [IMP]
- neuron projection morphogenesis [ISO]
- osteoblast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [ISO]
- positive regulation of cell communication by chemical coupling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glomerular filtration [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of striated muscle tissue development [IMP]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein oligomerization [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of blood vessel remodeling [TAS]
- regulation of bone mineralization [IMP]
- regulation of bone remodeling [IMP]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
- regulation of tight junction assembly [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IGI, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IGI, IMP]
- response to pH [ISO]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [IDA]
- transmembrane transport [IDA, ISO]
- vascular transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- apical plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- connexon complex [ISO]
- contractile fiber [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- intercalated disc [IDA, ISO]
- intermediate filament [IDA]
- late endosome [ISO]
- lateral plasma membrane [IDA]
- lysosome [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- mitochondrial outer membrane [ISO]
- multivesicular body [ISO]
- plasma membrane [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits synaptic plasticity and hippocampus-dependent learning and memory. However, the signaling proteins that RGS14 natively engages to regulate plasticity are unknown. Here, we show ... [more]
J. Proteome Res. Dec. 06, 2017; 17(4);1700-1711 [Pubmed: 29518331]
Throughput
- High Throughput
Curated By
- BioGRID