BAIT
RGS14
RPIP1
regulator of G-protein signaling 14
GO Process (21)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- cell division [ISO]
- chromosome segregation [IMP]
- intracellular signal transduction [IDA]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IDA]
- mitotic nuclear division [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of synaptic plasticity [IMP]
- nucleocytoplasmic transport [IDA, ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of neurogenesis [ISO]
- regulation of DNA-templated transcription in response to stress [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- response to oxidative stress [ISO]
- spindle organization [IMP, ISO]
- visual learning [ISO]
- zygote asymmetric cell division [IMP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
Gene Ontology Cellular Component
- centrosome [IDA, ISO]
- cytoplasm [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- dendritic spine [IDA]
- nuclear body [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IBA, IDA, ISO]
- postsynaptic density [IDA]
- spindle [IDA, ISO]
- spindle pole [ISO]
Mus musculus
PREY
CAMK2D
2810011D23Rik, 8030469K03Rik, CaMK II, [d]-CaMKII
calcium/calmodulin-dependent protein kinase II, delta
GO Process (30)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcium ion transport [IDA, IMP]
- cardiac muscle cell contraction [ISO, ISS]
- cardiac muscle contraction [IDA]
- cell growth involved in cardiac muscle cell development [ISO]
- cellular potassium ion homeostasis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of Rac protein signal transduction [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein autophosphorylation [IMP, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [ISO]
- regulation of G2/M transition of mitotic cell cycle [ISO]
- regulation of cardiac muscle cell action potential [ISO]
- regulation of cell communication by electrical coupling [ISO]
- regulation of cellular localization [ISO]
- regulation of generation of L-type calcium current [ISO]
- regulation of membrane depolarization [ISO]
- regulation of relaxation of cardiac muscle [IGI, ISO]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of sodium ion transport [IDA]
- relaxation of cardiac muscle [ISO, ISS]
- response to hypoxia [ISO]
Gene Ontology Molecular Function- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [ISO, ISS]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [ISO, ISS]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
- T-tubule [IDA]
- axon initial segment [IDA]
- calcium channel complex [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- intercalated disc [IDA]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- sarcoplasmic reticulum [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits synaptic plasticity and hippocampus-dependent learning and memory. However, the signaling proteins that RGS14 natively engages to regulate plasticity are unknown. Here, we show ... [more]
J. Proteome Res. Dec. 06, 2017; 17(4);1700-1711 [Pubmed: 29518331]
Throughput
- High Throughput
Curated By
- BioGRID