BAIT
RGS14
RPIP1
regulator of G-protein signaling 14
GO Process (21)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- cell division [ISO]
- chromosome segregation [IMP]
- intracellular signal transduction [IDA]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IDA]
- mitotic nuclear division [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of synaptic plasticity [IMP]
- nucleocytoplasmic transport [IDA, ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of neurogenesis [ISO]
- regulation of DNA-templated transcription in response to stress [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- response to oxidative stress [ISO]
- spindle organization [IMP, ISO]
- visual learning [ISO]
- zygote asymmetric cell division [IMP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
Gene Ontology Cellular Component
- centrosome [IDA, ISO]
- cytoplasm [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- dendritic spine [IDA]
- nuclear body [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IBA, IDA, ISO]
- postsynaptic density [IDA]
- spindle [IDA, ISO]
- spindle pole [ISO]
Mus musculus
PREY
ANK2
AI835472, AW491075, Ank-2
ankyrin 2, brain
GO Process (33)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [IMP]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [IMP]
- cardiac muscle contraction [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular protein localization [IMP]
- positive regulation of calcium ion transmembrane transporter activity [IMP]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cation channel activity [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of potassium ion transmembrane transporter activity [IMP]
- positive regulation of potassium ion transport [IMP]
- protein localization [IMP]
- protein localization to M-band [IMP]
- protein localization to T-tubule [IMP]
- protein localization to cell surface [IMP]
- protein localization to endoplasmic reticulum [IMP]
- protein localization to plasma membrane [IMP]
- protein stabilization [IMP]
- protein targeting to plasma membrane [IGI, IMP]
- regulation of calcium ion transmembrane transporter activity [IMP]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle cell membrane potential [IGI, IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, IMP]
- regulation of cation channel activity [IMP]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of protein stability [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- A band [IDA]
- M band [IDA, IMP]
- T-tubule [IDA]
- Z disc [IDA]
- cell [IGI]
- costamere [IDA]
- cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intercalated disc [IDA]
- intracellular [IGI, IMP]
- neuronal postsynaptic density [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP]
- sarcolemma [IDA, IMP]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits synaptic plasticity and hippocampus-dependent learning and memory. However, the signaling proteins that RGS14 natively engages to regulate plasticity are unknown. Here, we show ... [more]
J. Proteome Res. Dec. 06, 2017; 17(4);1700-1711 [Pubmed: 29518331]
Throughput
- High Throughput
Curated By
- BioGRID