BAIT
RGS14
RPIP1
regulator of G-protein signaling 14
GO Process (21)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- cell division [ISO]
- chromosome segregation [IMP]
- intracellular signal transduction [IDA]
- learning [IMP]
- long-term memory [IMP]
- long-term synaptic potentiation [IDA]
- mitotic nuclear division [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of synaptic plasticity [IMP]
- nucleocytoplasmic transport [IDA, ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of GTPase activity [IBA, ISO]
- positive regulation of neurogenesis [ISO]
- regulation of DNA-templated transcription in response to stress [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- response to oxidative stress [ISO]
- spindle organization [IMP, ISO]
- visual learning [ISO]
- zygote asymmetric cell division [IMP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
- G-protein alpha-subunit binding [ISO]
- GDP-dissociation inhibitor activity [ISO]
- GTPase activating protein binding [IPI]
- GTPase activator activity [IBA, IDA, ISO, TAS]
- microtubule binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- receptor signaling protein activity [IDA]
Gene Ontology Cellular Component
- centrosome [IDA, ISO]
- cytoplasm [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- dendritic spine [IDA]
- nuclear body [IDA]
- nucleus [IDA, ISO]
- plasma membrane [IBA, IDA, ISO]
- postsynaptic density [IDA]
- spindle [IDA, ISO]
- spindle pole [ISO]
Mus musculus
PREY
SLC9A3R1
EBP-50, NHE-RF, NHERF-1, NHERF1, RP23-342L24.4
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
GO Process (26)
GO Function (13)
GO Component (19)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- adenylate cyclase-activating dopamine receptor signaling pathway [IMP]
- auditory receptor cell stereocilium organization [IMP]
- bile acid secretion [IMP]
- cAMP-mediated signaling [IMP, ISA]
- cellular phosphate ion homeostasis [IMP]
- cellular protein localization [IMP]
- glutathione transport [IMP]
- microvillus assembly [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of cell migration [IGI]
- negative regulation of cell motility [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [IGI, IMP]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IMP]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of sodium ion transport [IMP]
- negative regulation of sodium:proton antiporter activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- regulation of excretion [IMP]
- regulation of protein kinase activity [IMP]
- renal absorption [IMP]
- renal phosphate ion absorption [ISO]
- renal sodium ion transport [IMP]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- beta-catenin binding [ISO]
- chloride channel regulator activity [ISO]
- dopamine receptor binding [IDA]
- growth factor receptor binding [ISO]
- phosphatase binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein self-association [ISO]
- receptor binding [ISO]
- PDZ domain binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- beta-catenin binding [ISO]
- chloride channel regulator activity [ISO]
- dopamine receptor binding [IDA]
- growth factor receptor binding [ISO]
- phosphatase binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein self-association [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA, ISO]
- brush border membrane [IDA]
- cell [IMP]
- cell periphery [ISO]
- centrosome [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- microvillus [ISO]
- microvillus membrane [ISO]
- plasma membrane [ISO]
- sperm midpiece [IDA]
- stereocilium [IDA]
- stereocilium bundle tip [IDA]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits synaptic plasticity and hippocampus-dependent learning and memory. However, the signaling proteins that RGS14 natively engages to regulate plasticity are unknown. Here, we show ... [more]
J. Proteome Res. Dec. 06, 2017; 17(4);1700-1711 [Pubmed: 29518331]
Throughput
- High Throughput
Curated By
- BioGRID