BAIT
PPP1R9B
Neb2
protein phosphatase 1, regulatory subunit 9B
GO Process (9)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- actin filament organization [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO, ISS]
- cellular response to morphine [ISO, ISS]
- dendrite development [ISO]
- filopodium assembly [ISO, ISS]
- negative regulation of cell growth [ISO]
- regulation of opioid receptor signaling pathway [ISO, ISS]
- regulation of protein phosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CAMK2D
CAMK1, Camk2, Camki, RATCAMKI
calcium/calmodulin-dependent protein kinase II delta
GO Process (33)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- calcium ion transport [ISO]
- cardiac muscle cell contraction [IDA]
- cardiac muscle contraction [ISO]
- cell growth involved in cardiac muscle cell development [IMP]
- cellular potassium ion homeostasis [IMP]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of Rac protein signal transduction [IMP]
- positive regulation of cardiac muscle hypertrophy [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- protein autophosphorylation [IDA, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [IDA, ISO, ISS]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cardiac muscle cell action potential [IDA]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of cell communication by electrical coupling [IDA]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cellular localization [ISO, ISS]
- regulation of generation of L-type calcium current [IDA]
- regulation of membrane depolarization [ISO]
- regulation of relaxation of cardiac muscle [IDA, ISO]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of sodium ion transport [ISO]
- relaxation of cardiac muscle [IDA]
- response to hypoxia [IMP]
Gene Ontology Molecular Function- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [IDA, IMP, ISO]
- ion channel binding [IDA, IPI, ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [IDA, IMP, ISO]
- ion channel binding [IDA, IPI, ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
- T-tubule [ISO]
- axon initial segment [ISO]
- calcium channel complex [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- intercalated disc [ISO]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
- sarcoplasmic reticulum [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.
Spinophilin regulates excitatory postsynaptic function and morphology during development by virtue of its interactions with filamentous actin, protein phosphatase 1, and a plethora of additional signaling proteins. To provide insight into the roles of spinophilin in mature brain, we characterized the spinophilin interactome in subcellular fractions solubilized from adult rodent striatum by using a shotgun proteomics approach to identify proteins ... [more]
Mol. Cell Proteomics Jun. 01, 2010; 9(6);1243-59 [Pubmed: 20124353]
Throughput
- Low Throughput
Curated By
- BioGRID