BAIT
CTBP2
RP11-59C5.2
C-terminal binding protein 2
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DLG1
DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg
discs, large homolog 1 (Drosophila)
GO Process (17)
GO Function (11)
GO Component (17)
Gene Ontology Biological Process
- actin filament organization [IDA]
- axon guidance [TAS]
- cortical actin cytoskeleton organization [IDA]
- dephosphorylation [TAS]
- endothelial cell proliferation [IDA]
- establishment or maintenance of cell polarity [TAS]
- mitotic cell cycle checkpoint [NAS]
- negative regulation of mitotic cell cycle [IMP]
- nucleotide phosphorylation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of potassium ion transport [IDA]
- protein localization to plasma membrane [IMP, TAS]
- regulation of membrane potential [IDA]
- regulation of sodium ion transmembrane transport [TAS]
- single organismal cell-cell adhesion [IDA]
- synaptic transmission [TAS]
- tight junction assembly [IDA]
Gene Ontology Molecular Function- L27 domain binding [IPI]
- cytoskeletal protein binding [TAS]
- guanylate kinase activity [TAS]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- phosphatase binding [IPI]
- phosphoprotein phosphatase activity [TAS]
- potassium channel regulator activity [IDA, NAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- L27 domain binding [IPI]
- cytoskeletal protein binding [TAS]
- guanylate kinase activity [TAS]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- phosphatase binding [IPI]
- phosphoprotein phosphatase activity [TAS]
- potassium channel regulator activity [IDA, NAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MPP7-DLG1-LIN7 complex [IDA]
- basolateral plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- cytosol [TAS]
- endoplasmic reticulum [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [TAS]
- intercalated disc [TAS]
- microtubule [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [TAS]
- tight junction [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex.
Atrophic nonunion, a complicated failure of fracture healing, is still obscure regarding its molecular pathological mechanisms. Carboxyl-terminal binding proteins (CtBPs), an NADH-sensitive transcriptional corepressor family, are involved in many diseases, such as cancer and inflammation. Here, we found that CtBP2, but not CtBP1, was significantly overexpressed in atrophic nonunion tissues compared to healthy controls. Using a mass spectrometry assay, we ... [more]
Int. J. Biol. Sci. Dec. 27, 2018; 14(14);2023-2036 [Pubmed: 30585266]
Throughput
- High Throughput
Curated By
- BioGRID