BAIT
CTBP2
RP11-59C5.2
C-terminal binding protein 2
GO Process (6)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GDF6
BMP-13, BMP13, CDMP2, KFM, KFS, KFS1, KFSL, LCA17, MCOP4, MCOPCB6, SCDO4, SGM1
growth differentiation factor 6
GO Process (11)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IBA]
- activin receptor signaling pathway [IDA]
- apoptotic process [ISS]
- cell development [IBA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- retinal cell apoptotic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex.
Atrophic nonunion, a complicated failure of fracture healing, is still obscure regarding its molecular pathological mechanisms. Carboxyl-terminal binding proteins (CtBPs), an NADH-sensitive transcriptional corepressor family, are involved in many diseases, such as cancer and inflammation. Here, we found that CtBP2, but not CtBP1, was significantly overexpressed in atrophic nonunion tissues compared to healthy controls. Using a mass spectrometry assay, we ... [more]
Int. J. Biol. Sci. Dec. 27, 2018; 14(14);2023-2036 [Pubmed: 30585266]
Throughput
- High Throughput
Curated By
- BioGRID