BAIT
GNAI1
Gi
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GO Process (8)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- cell division [IMP]
- platelet activation [TAS]
- response to peptide hormone [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DRD4
D4DR
dopamine receptor D4
GO Process (24)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult locomotory behavior [ISS]
- arachidonic acid secretion [IDA]
- behavioral fear response [NAS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [TAS]
- cellular calcium ion homeostasis [IC]
- dopamine metabolic process [IC]
- dopamine receptor signaling pathway [IDA]
- fear response [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP biosynthetic process [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of voltage-gated calcium channel activity [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [IC]
- positive regulation of kinase activity [IDA]
- positive regulation of sodium:proton antiporter activity [IDA]
- regulation of circadian rhythm [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- response to amphetamine [ISS]
- response to histamine [IDA]
- social behavior [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
D2-like dopamine and ?-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase.
?-Adrenergic receptors (?AR) and D(2)-like dopamine receptors (which include D(2)-, D(3)- and D(4)-dopamine receptors) activate G(s) and G(i), the stimulatory and inhibitory heterotrimeric G proteins, respectively, which in turn regulate the activity of adenylyl cyclase (AC). ?(2)-Adrenergic receptors (?(2)AR) and D(4)-dopamine receptors (D(4)DR) co-immunoprecipitated when co-expressed in HEK 293 cells, suggesting the existence of a signaling complex containing both receptors. ... [more]
Cell. Signal. Nov. 01, 2012; 24(11);2051-60 [Pubmed: 22759790]
Throughput
- Low Throughput
Curated By
- BioGRID