IGBP1
Gene Ontology Biological Process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of stress-activated MAPK cascade [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of microtubule-based movement [IMP]
- response to interleukin-1 [IMP]
- response to tumor necrosis factor [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
ARHGEF7
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- focal adhesion assembly [IDA]
- lamellipodium assembly [ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of apoptotic process [IMP, TAS]
- positive regulation of fibroblast migration [IDA]
- positive regulation of lamellipodium morphogenesis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
?4 Coordinates Small Intestinal Epithelium Homeostasis by Regulating Stability of HuR.
The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis depends on a dynamic balance among proliferation, migration, apoptosis, and differentiation of intestinal epithelial cells (IECs). The protein phosphatase 2A (PP2A)-associated protein ?4 controls the activity and specificity of serine/threonine phosphatases and is thus implicated in many cellular processes. Here, using a genetic approach, we ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID