BAIT
ITGA5
Cd49e, Fnra, VLA5
integrin alpha 5 (fibronectin receptor alpha)
GO Process (14)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- cell adhesion [ISO]
- cell-cell adhesion mediated by integrin [IMP]
- cell-substrate adhesion [ISO]
- cell-substrate junction assembly [IDA]
- endodermal cell differentiation [ISO]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IMP]
- heterotypic cell-cell adhesion [ISO]
- integrin-mediated signaling pathway [ISO]
- leukocyte cell-cell adhesion [IMP]
- memory [IMP]
- negative regulation of anoikis [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
VPS26B
1810012I05Rik, 2310075A12Rik, AI848392
vacuolar protein sorting 26 homolog B (yeast)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID