BAIT
ITGA2B
AI172977, CD41, CD41B, GpIIb, alphaIIb, RP23-226P4.6
integrin alpha 2b
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CORO1A
Clabp, Lmb3, TACO, p57
coronin, actin binding protein 1A
GO Process (26)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- T cell homeostasis [IMP]
- actin cytoskeleton organization [ISO]
- actin filament organization [IMP]
- calcium ion transport [IMP]
- cell migration [IMP]
- cell-substrate adhesion [ISO]
- cellular response to interleukin-4 [IDA]
- early endosome to recycling endosome transport [IMP]
- homeostasis of number of cells within a tissue [IMP]
- leukocyte chemotaxis [IMP]
- negative regulation of actin nucleation [IBA, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of vesicle fusion [IMP]
- nerve growth factor signaling pathway [IGI]
- phagocytosis [ISO]
- phagolysosome assembly [IBA, ISO]
- positive chemotaxis [IBA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of cell migration [IMP]
- regulation of actin filament polymerization [IMP]
- regulation of actin polymerization or depolymerization [IMP]
- regulation of cell shape [IMP]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- response to cytokine [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- actin filament [ISO]
- axon [IDA]
- cell [IMP]
- cell leading edge [IDA]
- cell-cell junction [IDA]
- cortical actin cytoskeleton [IBA, ISO]
- cytoplasm [ISO]
- early endosome [IDA]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- intracellular [IMP]
- lamellipodium [IBA, ISO]
- membrane [ISO]
- phagocytic cup [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID