BAIT
ITGA2B
AI172977, CD41, CD41B, GpIIb, alphaIIb, RP23-226P4.6
integrin alpha 2b
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NME1
AL024257, NDPK-A, NM23-M1, NM23A, RP23-378I13.1
NME/NM23 nucleoside diphosphate kinase 1
GO Process (14)
GO Function (14)
GO Component (10)
Gene Ontology Biological Process
- DNA catabolic process [ISO]
- lactation [IMP]
- mammary gland development [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of myeloid leukocyte differentiation [ISO]
- nucleic acid phosphodiester bond hydrolysis [ISO]
- nucleoside diphosphate phosphorylation [IBA, ISO]
- nucleoside triphosphate biosynthetic process [IBA]
- positive regulation of DNA binding [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- purine nucleotide metabolic process [IBA]
- pyrimidine nucleotide metabolic process [IBA]
- regulation of apoptotic process [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID