ITGA2B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CAT
Gene Ontology Biological Process
- UV protection [ISO]
- aerobic respiration [IMP]
- cholesterol metabolic process [IMP]
- hemoglobin metabolic process [IMP]
- hydrogen peroxide catabolic process [IDA, IMP, ISO]
- kidney development [ISO]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of apoptotic process [ISO]
- osteoblast differentiation [ISO]
- oxidation-reduction process [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- protein homotetramerization [ISO]
- protein tetramerization [ISO]
- response to hypoxia [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [ISO]
- triglyceride metabolic process [IMP]
- ureteric bud development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [ISO]
- membrane [ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA]
- peroxisomal membrane [IDA]
- peroxisome [IDA, ISO]
- plasma membrane [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
Throughput
- High Throughput
Curated By
- BioGRID