BAIT
ITGA2B
AI172977, CD41, CD41B, GpIIb, alphaIIb, RP23-226P4.6
integrin alpha 2b
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CAT
2210418N07, Cas-1, Cas1, Cs-1, RP23-266F3.2
catalase
GO Process (19)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- UV protection [ISO]
- aerobic respiration [IMP]
- cholesterol metabolic process [IMP]
- hemoglobin metabolic process [IMP]
- hydrogen peroxide catabolic process [IDA, IMP, ISO]
- kidney development [ISO]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of apoptotic process [ISO]
- osteoblast differentiation [ISO]
- oxidation-reduction process [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- protein homotetramerization [ISO]
- protein tetramerization [ISO]
- response to hypoxia [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [ISO]
- triglyceride metabolic process [IMP]
- ureteric bud development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [ISO]
- membrane [ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA]
- peroxisomal membrane [IDA]
- peroxisome [IDA, ISO]
- plasma membrane [ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID