ITGA2B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
G6PDX
Gene Ontology Biological Process
- NADP biosynthetic process [IDA, IMP]
- NADP metabolic process [ISO]
- NADPH regeneration [ISO]
- angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure [IMP]
- cellular response to oxidative stress [ISO]
- cholesterol biosynthetic process [ISO]
- cytokine production [IMP, ISO]
- erythrocyte development [IMP]
- erythrocyte maturation [ISO]
- glucose 6-phosphate metabolic process [ISO]
- glutathione metabolic process [IMP, ISO]
- interleukin-10 production [IMP]
- interleukin-12 production [IMP]
- negative regulation of protein glutathionylation [ISO]
- oxidation-reduction process [IMP, ISO]
- pentose biosynthetic process [IDA, IMP, ISO]
- pentose-phosphate shunt [ISO]
- pentose-phosphate shunt, oxidative branch [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of neuron apoptotic process [ISO]
- response to ethanol [ISO]
- response to oxidative stress [IMP]
- ribose phosphate biosynthetic process [ISO]
- vasodilation by angiotensin involved in regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
Throughput
- High Throughput
Curated By
- BioGRID