BAIT

ITGA2B

AI172977, CD41, CD41B, GpIIb, alphaIIb, RP23-226P4.6
integrin alpha 2b
Mus musculus
PREY

ARPC3

1110006A04Rik, 21kDa, AA408672, AI788639, p21-Ar, p21Arc
actin related protein 2/3 complex, subunit 3
GO Process (1)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.

Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Faessler R, Boettcher RT

Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]

J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]

Throughput

  • High Throughput

Curated By

  • BioGRID