BAIT
ITGB1
4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa
integrin beta 1 (fibronectin receptor beta)
GO Process (47)
GO Function (18)
GO Component (34)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- axon extension [IGI, IMP]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue development [IMP]
- cell adhesion [ISO]
- cell fate specification [IMP]
- cell migration [IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cell-matrix adhesion [IGI, IMP, ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [ISO]
- dendrite morphogenesis [IGI, IMP]
- formation of radial glial scaffolds [IMP]
- germ cell migration [IMP]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [IMP]
- integrin-mediated signaling pathway [ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- neuron projection development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein transport within lipid bilayer [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell cycle [IMP]
- regulation of collagen catabolic process [ISO]
- sarcomere organization [IMP]
- stress fiber assembly [IMP]
- tight junction assembly [ISO]
- tissue homeostasis [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- acrosomal vesicle [ISO]
- adherens junction [ISO]
- basement membrane [ISO]
- cell surface [IDA, ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendritic spine [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- hemidesmosome [ISO]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [ISO]
- integrin alpha7-beta1 complex [IDA, IPI]
- integrin alpha9-beta1 complex [ISO]
- integrin complex [ISO]
- intercalated disc [IDA]
- invadopodium membrane [ISO]
- membrane [ISO]
- membrane raft [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
- synaptic membrane [IDA]
Mus musculus
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID