BAIT
ITGB1
4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa
integrin beta 1 (fibronectin receptor beta)
GO Process (47)
GO Function (18)
GO Component (34)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- axon extension [IGI, IMP]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue development [IMP]
- cell adhesion [ISO]
- cell fate specification [IMP]
- cell migration [IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cell-matrix adhesion [IGI, IMP, ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [ISO]
- dendrite morphogenesis [IGI, IMP]
- formation of radial glial scaffolds [IMP]
- germ cell migration [IMP]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [IMP]
- integrin-mediated signaling pathway [ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- neuron projection development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein transport within lipid bilayer [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell cycle [IMP]
- regulation of collagen catabolic process [ISO]
- sarcomere organization [IMP]
- stress fiber assembly [IMP]
- tight junction assembly [ISO]
- tissue homeostasis [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- acrosomal vesicle [ISO]
- adherens junction [ISO]
- basement membrane [ISO]
- cell surface [IDA, ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendritic spine [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- hemidesmosome [ISO]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [ISO]
- integrin alpha7-beta1 complex [IDA, IPI]
- integrin alpha9-beta1 complex [ISO]
- integrin complex [ISO]
- intercalated disc [IDA]
- invadopodium membrane [ISO]
- membrane [ISO]
- membrane raft [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
- synaptic membrane [IDA]
Mus musculus
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID