BAIT
ITGB1
4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa
integrin beta 1 (fibronectin receptor beta)
GO Process (47)
GO Function (18)
GO Component (34)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- axon extension [IGI, IMP]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [IMP]
- cardiac muscle tissue development [IMP]
- cell adhesion [ISO]
- cell fate specification [IMP]
- cell migration [IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cell-matrix adhesion [IGI, IMP, ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [ISO]
- dendrite morphogenesis [IGI, IMP]
- formation of radial glial scaffolds [IMP]
- germ cell migration [IMP]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [IMP]
- integrin-mediated signaling pathway [ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- neuron projection development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein transport within lipid bilayer [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell cycle [IMP]
- regulation of collagen catabolic process [ISO]
- sarcomere organization [IMP]
- stress fiber assembly [IMP]
- tight junction assembly [ISO]
- tissue homeostasis [ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- actin binding [ISO]
- alpha-actinin binding [ISO]
- cell adhesion molecule binding [ISO]
- collagen binding [ISO]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [ISO]
- glycoprotein binding [ISO]
- integrin binding [IPI, ISO]
- kinase binding [ISO]
- laminin binding [IDA, ISO]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- acrosomal vesicle [ISO]
- adherens junction [ISO]
- basement membrane [ISO]
- cell surface [IDA, ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- dendritic spine [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- hemidesmosome [ISO]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [ISO]
- integrin alpha7-beta1 complex [IDA, IPI]
- integrin alpha9-beta1 complex [ISO]
- integrin complex [ISO]
- intercalated disc [IDA]
- invadopodium membrane [ISO]
- membrane [ISO]
- membrane raft [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
- synaptic membrane [IDA]
Mus musculus
PREY
PRKDC
AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
protein kinase, DNA activated, catalytic polypeptide
GO Process (36)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell lineage commitment [IMP]
- T cell differentiation in thymus [IMP]
- T cell lineage commitment [IMP]
- T cell receptor V(D)J recombination [IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cellular response to insulin stimulus [ISO]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [IMP]
- ectopic germ cell programmed cell death [IMP]
- heart development [IGI]
- immunoglobulin V(D)J recombination [IMP]
- immunoglobulin production [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- lymphocyte differentiation [IMP]
- negative regulation of cellular senescence [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of response to gamma radiation [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [IBA]
- positive regulation of apoptotic process [IMP]
- positive regulation of developmental growth [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of immune system process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- pro-B cell differentiation [IMP]
- protein destabilization [IDA]
- protein phosphorylation [IDA]
- regulation of circadian rhythm [IMP]
- response to gamma radiation [IMP]
- signal transduction involved in mitotic G1 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
- spleen development [ISO]
- telomere maintenance [IMP]
- thymus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID