BAIT
ITGB3
CD61, GP3A, INGRB3, RP24-460H24.1
integrin beta 3
GO Process (45)
GO Function (11)
GO Component (18)
Gene Ontology Biological Process
- activation of protein kinase activity [ISO]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- cell adhesion [ISO]
- cell growth [ISO]
- cell migration [ISO]
- cell projection morphogenesis [IC]
- cell-matrix adhesion [IGI, ISO]
- cell-substrate adhesion [ISO]
- cell-substrate junction assembly [IDA]
- cellular calcium ion homeostasis [ISO]
- heterotypic cell-cell adhesion [ISO]
- integrin-mediated signaling pathway [ISO]
- negative chemotaxis [ISO]
- negative regulation of cell death [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of lipoprotein metabolic process [ISO]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- platelet activation [ISO]
- platelet aggregation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of bone resorption [IC, ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of glomerular mesangial cell proliferation [ISO]
- positive regulation of leukocyte migration [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of osteoclast differentiation [IC]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein folding [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell migration [IMP]
- regulation of release of sequestered calcium ion into cytosol [ISO]
- smooth muscle cell migration [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- viral entry into host cell [ISO]
Gene Ontology Molecular Function- cell adhesion molecule binding [ISO]
- extracellular matrix binding [ISO]
- fibrinogen binding [ISO]
- fibronectin binding [ISO]
- identical protein binding [ISO]
- integrin binding [IPI]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein disulfide isomerase activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- cell adhesion molecule binding [ISO]
- extracellular matrix binding [ISO]
- fibrinogen binding [ISO]
- fibronectin binding [ISO]
- identical protein binding [ISO]
- integrin binding [IPI]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein disulfide isomerase activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- alpha9-beta1 integrin-ADAM8 complex [IDA]
- apical plasma membrane [IDA, ISO]
- cell surface [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- integrin alpha9-beta1 complex [TAS]
- integrin alphav-beta3 complex [ISO]
- integrin complex [ISO]
- lamellipodium membrane [ISO]
- melanosome [ISO]
- membrane [ISO]
- microvillus membrane [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
Mus musculus
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID