BAIT
ITGB3
CD61, GP3A, INGRB3, RP24-460H24.1
integrin beta 3
GO Process (45)
GO Function (11)
GO Component (18)
Gene Ontology Biological Process
- activation of protein kinase activity [ISO]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- cell adhesion [ISO]
- cell growth [ISO]
- cell migration [ISO]
- cell projection morphogenesis [IC]
- cell-matrix adhesion [IGI, ISO]
- cell-substrate adhesion [ISO]
- cell-substrate junction assembly [IDA]
- cellular calcium ion homeostasis [ISO]
- heterotypic cell-cell adhesion [ISO]
- integrin-mediated signaling pathway [ISO]
- negative chemotaxis [ISO]
- negative regulation of cell death [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of lipoprotein metabolic process [ISO]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- platelet activation [ISO]
- platelet aggregation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of bone resorption [IC, ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of glomerular mesangial cell proliferation [ISO]
- positive regulation of leukocyte migration [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of osteoclast differentiation [IC]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein folding [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of cell migration [IMP]
- regulation of release of sequestered calcium ion into cytosol [ISO]
- smooth muscle cell migration [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- viral entry into host cell [ISO]
Gene Ontology Molecular Function- cell adhesion molecule binding [ISO]
- extracellular matrix binding [ISO]
- fibrinogen binding [ISO]
- fibronectin binding [ISO]
- identical protein binding [ISO]
- integrin binding [IPI]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein disulfide isomerase activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- cell adhesion molecule binding [ISO]
- extracellular matrix binding [ISO]
- fibrinogen binding [ISO]
- fibronectin binding [ISO]
- identical protein binding [ISO]
- integrin binding [IPI]
- peptide binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein disulfide isomerase activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- alpha9-beta1 integrin-ADAM8 complex [IDA]
- apical plasma membrane [IDA, ISO]
- cell surface [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- integrin alpha9-beta1 complex [TAS]
- integrin alphav-beta3 complex [ISO]
- integrin complex [ISO]
- lamellipodium membrane [ISO]
- melanosome [ISO]
- membrane [ISO]
- microvillus membrane [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
- ruffle membrane [ISO]
Mus musculus
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
J. Cell. Sci. Dec. 21, 2017; 131(22); [Pubmed: 30333137]
Throughput
- High Throughput
Curated By
- BioGRID