ITGB2
Gene Ontology Biological Process
- activated T cell proliferation [IMP]
- cell adhesion [IGI, IMP]
- cell-matrix adhesion [ISO]
- cellular extravasation [IMP, ISO]
- endothelial cell migration [ISO]
- heterotypic cell-cell adhesion [ISO]
- integrin-mediated signaling pathway [IDA]
- leukocyte cell-cell adhesion [ISO]
- leukocyte migration involved in inflammatory response [ISO]
- natural killer cell activation [ISO]
- neutrophil chemotaxis [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- receptor clustering [ISO]
- regulation of peptidyl-tyrosine phosphorylation [ISO]
- signal transduction [ISO]
- single organismal cell-cell adhesion [IGI, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNK1
Gene Ontology Biological Process
- intracellular signal transduction [ISO]
- ion transport [IDA]
- negative regulation of kinase activity [ISO]
- negative regulation of pancreatic juice secretion [IMP]
- negative regulation of phosphatase activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of systemic arterial blood pressure [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cellular process [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
LCP1 preferentially binds clasped ?M?2 integrin and attenuates leukocyte adhesion under flow.
Integrins are ?/? heterodimers that interconvert between inactive and active states. In the active state the ?/? cytoplasmic domains recruit integrin-activating proteins and separate the transmembrane and cytoplasmic (TMcyto) domains (unclasped TMcyto). Conversely, in the inactive state the ?/? TMcyto domains bind integrin-inactivating proteins, resulting in the association of the TMcyto domains (clasped TMcyto). Here, we report the isolation of ... [more]
Throughput
- High Throughput
Curated By
- BioGRID