BAIT

XRCC1

RCC
X-ray repair complementing defective repair in Chinese hamster cells 1
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

ORC5

ORC5L, ORC5P, ORC5T, PPP1R117
origin recognition complex, subunit 5
Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks.

Kordon MM, Szczurek A, Berniak K, Szelest O, Solarczyk K, Tworzydlo M, Wachsmann-Hogiu S, Vaahtokari A, Cremer C, Pederson T, Dobrucki JW

DNA lesions induce recruitment and accumulation of various repair factors, resulting in formation of discrete nuclear foci. Using superresolution fluorescence microscopy as well as live cell and quantitative imaging, we demonstrate that X-ray repair cross-complementing protein 1 (XRCC1), a key factor in single-strand break and base excision repair, is recruited into nuclear bodies formed in response to replication-related single-strand breaks. ... [more]

FASEB J. Dec. 01, 2018; 33(2);2301-2313 [Pubmed: 30260704]

Throughput

  • Low Throughput

Additional Notes

  • assayed using 3D SIM (3D structured illumination microscopy)

Curated By

  • BioGRID