STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [ISO]
- intracellular protein transport [IBA]
- neurotransmitter transport [TAS]
- positive regulation of exocytosis [IDA]
- positive regulation of neurotransmitter secretion [IMP]
- regulation of exocytosis [IMP]
- response to gravity [IDA]
- secretion by cell [ISO]
- synaptic vesicle docking [IEP]
- synaptic vesicle fusion to presynaptic membrane [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
Gene Ontology Cellular Component
- SNARE complex [ISO, ISS]
- actomyosin [IDA]
- cell [ISO]
- integral component of membrane [NAS]
- intracellular organelle [IDA]
- membrane [ISO]
- neuron projection [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- secretory granule [IDA]
- synaptic vesicle [IBA, ISO]
- synaptic vesicle membrane [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
KCNMA1
Gene Ontology Biological Process
- adult walking behavior [ISO]
- auditory receptor cell differentiation [ISO]
- cell maturation [ISO]
- cellular potassium ion homeostasis [ISO]
- circadian rhythm [ISO]
- eye blink reflex [ISO]
- locomotor rhythm [ISO]
- micturition [ISO]
- negative regulation of cell volume [ISO]
- neuromuscular process controlling balance [ISO]
- neuronal action potential [ISO]
- positive regulation of apoptotic process [ISO]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [ISO]
- protein homooligomerization [ISO]
- protein homotetramerization [IDA]
- regulation of aldosterone metabolic process [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of vasodilation [IDA]
- relaxation of vascular smooth muscle [ISO]
- response to calcium ion [IDA, ISO]
- response to carbon monoxide [ISO]
- response to corticosteroid [IDA]
- response to estrogen [IDA]
- response to hypoxia [IDA, ISO]
- response to osmotic stress [ISO]
- response to pH [IDA]
- saliva secretion [ISO]
- sensory perception of sound [ISO]
- smooth muscle contraction involved in micturition [ISO]
- synaptic transmission [ISO]
- vasodilation [ISO]
Gene Ontology Molecular Function- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, ISO]
- large conductance calcium-activated potassium channel activity [IBA, IDA, ISO]
- potassium channel activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein homodimerization activity [IDA]
- voltage-gated potassium channel activity [IBA, ISO]
- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, ISO]
- large conductance calcium-activated potassium channel activity [IBA, IDA, ISO]
- potassium channel activity [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein homodimerization activity [IDA]
- voltage-gated potassium channel activity [IBA, ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IBA, ISO]
- caveola [ISO]
- cell [ISO]
- cytoplasm [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- presynaptic active zone membrane [IDA]
- protein complex [IDA]
- terminal bouton [ISO]
- voltage-gated potassium channel complex [IBA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Syntaxin 1A co-associates with native rat brain and cloned large conductance, calcium-activated potassium channels in situ.
Large conductance, calcium-activated potassium channels (BKCa channels) are regulated by several distinct mechanisms, including phosphorylation/dephosphorylation events and protein-protein interactions. In this study, we have examined the interaction between BKCa channels and syntaxin 1A, a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) that is reported to modulate the activity and/or localization of different classes of ion channels. Using a reciprocal co-immunoprecipitation ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNMA1 STX1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID