RES1
Gene Ontology Biological Process
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IC, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- transcription from RNA polymerase II promoter [IMP]
- traversing start control point of mitotic cell cycle [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- chromatin binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
POP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes can become dispensable for viability remain unclear. Here, we investigate 'bypass of essentiality (BOE)' - an underexplored type of digenic genetic interaction that renders essential genes dispensable. Through analyzing essential genes on one of the six chromosome arms of the fission yeast Schizosaccharomyces pombe, we ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RES1 POP2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.1358 | BioGRID | 792790 |