TDP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAD51
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes can become dispensable for viability remain unclear. Here, we investigate 'bypass of essentiality (BOE)' - an underexplored type of digenic genetic interaction that renders essential genes dispensable. Through analyzing essential genes on one of the six chromosome arms of the fission yeast Schizosaccharomyces pombe, we ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TDP1 RAD51 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 565362 | |
| TDP1 RAD51 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 565351 |