BAIT
SRC
AW259666, pp60c-src, RP23-169M4.1
Rous sarcoma oncogene
GO Process (29)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- bone resorption [IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell migration [IMP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- epidermal growth factor receptor signaling pathway [IBA]
- forebrain development [IGI]
- innate immune response [IBA]
- intracellular signal transduction [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [IBA]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- oogenesis [IMP]
- osteoclast development [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of podosome assembly [IDA, IGI]
- progesterone receptor signaling pathway [IBA]
- protein phosphorylation [IDA]
- regulation of cell cycle [IBA]
- regulation of cell projection assembly [IGI]
- regulation of cell proliferation [IBA]
- regulation of intracellular estrogen receptor signaling pathway [IMP]
- regulation of protein binding [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- uterus development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
Mus musculus
PREY
ANXA1
Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1
annexin A1
GO Process (25)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- DNA rewinding [ISO]
- DNA strand renaturation [ISO]
- alpha-beta T cell differentiation [IMP]
- arachidonic acid secretion [IMP]
- cell surface receptor signaling pathway [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- insulin secretion [ISO]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [ISO]
- negative regulation of protein secretion [ISO]
- neutrophil clearance [ISO]
- neutrophil homeostasis [IMP, ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of neutrophil apoptotic process [IMP]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [ISO]
- regulation of cell proliferation [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.769 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID