BAIT
TCP1
AI528772, CCT, Cct1, Ccta, TRic, Tcp-1, Tp63, c-cpn, p63, RP23-351C7.3
t-complex protein 1
GO Process (4)
GO Function (3)
GO Component (13)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- acrosomal vesicle [IDA]
- cell body [IDA]
- centrosome [ISO]
- chaperonin-containing T-complex [IDA]
- extracellular vesicular exosome [ISO]
- heterochromatin [ISO]
- microtubule [ISO]
- microtubule organizing center [IDA]
- myelin sheath [IDA]
- nuclear heterochromatin [IDA]
- pericentriolar material [IDA]
- zona pellucida receptor complex [IDA]
Mus musculus
PREY
APEX1
APE, Apex, HAP1, Ref-1
apurinic/apyrimidinic endonuclease 1
GO Process (15)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IBA, ISO]
- DNA catabolic process, exonucleolytic [IBA]
- DNA demethylation [ISO]
- DNA repair [ISO]
- RNA phosphodiester bond hydrolysis, endonucleolytic [ISO]
- aging [ISO]
- base-excision repair [IBA]
- cell redox homeostasis [IDA]
- cellular response to hydrogen peroxide [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- oxidation-reduction process [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of mRNA stability [ISO]
- regulation of nucleic acid-templated transcription [ISO]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [ISO]
- DNA binding [ISO]
- DNA-(apurinic or apyrimidinic site) lyase activity [IBA, ISO]
- NF-kappaB binding [ISO]
- chromatin DNA binding [ISO]
- damaged DNA binding [ISO]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endoribonuclease activity [ISO]
- metal ion binding [ISO]
- oxidoreductase activity [ISO]
- poly(A) RNA binding [ISO]
- protein complex binding [ISO]
- site-specific endodeoxyribonuclease activity, specific for altered base [ISO]
- transcription coactivator activity [ISO]
- 3'-5' exonuclease activity [ISO]
- DNA binding [ISO]
- DNA-(apurinic or apyrimidinic site) lyase activity [IBA, ISO]
- NF-kappaB binding [ISO]
- chromatin DNA binding [ISO]
- damaged DNA binding [ISO]
- double-stranded DNA 3'-5' exodeoxyribonuclease activity [IBA]
- endoribonuclease activity [ISO]
- metal ion binding [ISO]
- oxidoreductase activity [ISO]
- poly(A) RNA binding [ISO]
- protein complex binding [ISO]
- site-specific endodeoxyribonuclease activity, specific for altered base [ISO]
- transcription coactivator activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.745 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID